Summary
The in vivo distribution in man of the four platinum derivatives cis-dichlorodiammine platinum(II) (DDP), cis-trans-dichlorodihydroxy-bis-(isopropylamine) platinum (IV) (CHIP), cis-dichloro-bis-cyclopropylamine platinum (II) (CP), and cis-diammine 1,1-cyclobutanedicarboxylate platinum(II) (CBDCA) has been observed. The availability of these compounds labelled with the radioactive isotope of platinum, platinum-191, has made serial in vivo imaging of their distribution possible.
Injection of 17–35 MBq (5–28 mg) of the labelled compound IV was followed by imaging, using a gamma camera, with particular reference to the kidneys, liver, and tumour site.
Hepatic and renal clearances were observed in all nine patients, but no unequivocal evidence of tumour uptake was found. The left kidney uptake was estimated at times up to 7 days after injection. Mathematical analysis of some of the uptake curves failed to show any significant difference between the clearance times observed. However, the two patients who received CBDCA did show a higher initial renal uptake, falling within the 1st day to levels comparable with those of the other compounds, and the three patients who received DDP showed consistently liver uptake.
Similar content being viewed by others
References
Einhorn LH, Williams SD (1979) The role of cis-platinum in solid-tumour, therapy. N Engl J Med 300:289–291
Harrison H, McAuliffe CA, Zaki A, Baer J, Sharma H, Smith A, Jackson H, Fox BW (1983) A comparative study of the distribution in the male rat of platinum-labelled cis-dichlorodiammine platinum (II), cis-trans-dichlorodihydroxy-bis-(isopropylamine) platinum (IV), and cis-dichloro-bis-cyclopropylamine platinum (II) Cancer Chemother Pharmacol 10:90–95
Kidani Y, Inagaki K, Saito R, Tsukagoshi S (1977) Synthesis and anti-tumour activities of platinum (II) complexes of 1,2-diamminocyclohexane isomers and their related derivatives. J Clin Haematol Oncol 7:197–209
Lange RC, Spencer RP, Harder HC (1973) The antitumour agent cis-Pt(NH3)2Cl2: Distribution studies and dose calculation for 193mPt and 195mPt. J Nucl Med 14:191–195
Prestayko AW, D'Aoust JC, Issell BF, Cooke ST (1979) cis-Platin (cis-diammine dichloroplatinum II). Cancer Treat Rev 6:17–39
Sharma H, Smith AG (1981) The short-lived radioisotope production programme at Manchester. J Radioanal Chem 64:249–255
Sharma H, Thatcher N, Baer J, Zaki A, McAuliffe CA, Growther D, Owens S, Fox BW (1983) Blood clearance of radioactively labelled cis-diammine 1,1-cyclobutanedicarboxylate platinum(II) (CBDCA) in cancer patients. Cancer Chemother Pharmacol 11:5–7
Smith PHS, Taylor DM (1974) Distribution and retention of the antitumour agent 195mPt-cis-dichlorodiammine platinum(II) in man. J Nucl Med 15:349–351
Speer RJ, Ridgway H, Stewart DP, Hall LM, Zapata A, Hill JM (1977) Sulfato-1,2-diamincyclohexane platinum (II): A potential new antitumour agent. J Clin Haematol Oncol 7:210–219
Thatcher N, Sharma H, Harrison R, Smith A, Zaki A, McAuliffe CA, Fox BW, Crowther D (1982) Blood clearance of three radioactively labelled platinum complexes, cis-dichlorodiammine platinum(II), cis-trans-dichlorodihydroxy-bis-(isopropylamine) platinum(IV) and cis-dichloro-bis-cyclopropylamine platinum(II) in patients with malignant disease. Cancer Chemother Pharmacol 9:13–16
Tobe ML, Khokhar AR (1977) Structure, activity, reactivity and solubility relationships of platinum diamine complexes. J Clin Haematol Oncol 7:114–137
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Owens, S.E., Thatcher, N., Sharma, H. et al. In vivo distribution studies of radioactively labelled platinum complexes; cis-dichlorodiammine platinum(II), cis-trans-dichlorodihydroxy-bis-(isopropylamine) platinum (IV), cis-dichloro-bis-cyclopropylamine platinum(II), and cis-diammine 1,1-cyclobutanedicarboxylate platinum(II) in patients with malignant disease, using a gamma camera. Cancer Chemother. Pharmacol. 14, 253–257 (1985). https://doi.org/10.1007/BF00258128
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00258128